(HealthDay News) — Neither marine omega-3 fatty acids, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), nor vitamin D3 are associated with a reduction in the risk for incident atrial fibrillation (AF), according to a study published in the Journal of the American Medical Association.

Christine M. Albert, MD, MPH, from Cedars-Sinai Medical Center in Los Angeles, and colleagues examined the effects of long-term administration of supplementation with marine omega-3 fatty acids and vitamin D on incident AF in an ancillary 2 x 2 factorial randomized clinical trial involving 25,119 women and men aged 50 years or older. Participants were randomly assigned to EPA-DHA and vitamin D3 (6272 analyzed); EPA-DHA and placebo (6270 analyzed); vitamin D3 and placebo (6281 analyzed); or 2 placebos (6296 analyzed).

The researchers found that the primary end point of incident AF occurred in 3.6% of the study participants during a median of 5.3 years of treatment and follow-up. Incident AF events occurred in 3.7 and 3.4% of participants for the EPA-DHA versus placebo comparison (hazard ratio, 1.09; 95% confidence interval, 0.96 to 1.24; P = 0.19). Incident AF events occurred in 3.7 and 3.4 percent of participants for the vitamin D3 versus placebo comparison (hazard ratio, 1.09; 95% confidence interval, 0.96 to 1.25; P=.19). No evidence was seen for an interaction between the two study agents (hazard ratio, 1.07; 95% confidence interval, 0.92 to 1.25; P=.39).

Continue Reading

“The findings do not support the use of either agent for the primary prevention of incident AF,” the authors write.

Pharmavite LLC provided the vitamin D/placebo for the trial, and Quest Diagnostics performed the serum 25-hydroxyvitamin D and plasma phospholipid omega-3 measurements. Pronova BioPharma/BASF donated omega-3 fatty acids.


Albert CM, Cook NR, Pester J, et al. Effect of marine omega-3 fatty acid and vitamin D supplementation on incident atrial fibrillation: a randomized clinical trial. JAMA. 2021;325(11):1061-1073. doi:10.1001/jama.2021.1489

Curfman G. Omega-3 fatty acids and atrial fibrillation. JAMA. 2021;325(11):1063. doi:10.1001/jama.2021.2909