(HealthDay News) — Recovery from metabolic syndrome (MetS) is associated with a decreased risk for major adverse cardiovascular events (MACE), while increased risk is seen in association with MetS development, according to a study published online in the Annals of Internal Medicine.
Sehoon Park, MD, from the Seoul National University College of Medicine in South Korea, and colleagues conducted a nationwide cohort study to examine whether recovery from or development of MetS is associated with an altered risk for MACE. The MetS status of 9,553,042 persons was determined and classified as MetS-chronic (1,486,485), MetS-developed (587,088), MetS-recovery (538,806), and MetS-free (6,940,663).
The researchers found that compared with the MetS-chronic group, the MetS-recovery group had a significantly lower MACE risk at a median follow-up of 3.54 years (incidence rate, 4.55 vs 8.52 per 1000 person-years; adjusted incidence rate ratio, 0.85). Compared with the MetS-free group, the MetS-developed group had a significantly higher MACE risk (incidence rate, 6.05 vs 1.92 per 1000 person-years; adjusted incidence rate ratio, 1.36). Among the MetS components, the largest difference in MACE risk was seen for change in hypertension.
“Further trials with population-scale interventions to reduce the burden of MACE by preventing or reducing MetS are warranted to confirm the benefits of recovery from or prevention of MetS,” the authors write.