In a study of 436 patients with chronic kidney disease not on dialysis (mean age 65.1 years), ambulatory blood pressure (BP) measurements showed risk of both renal and cardiovascular (CV) events to be highest when daytime systolic BP was 135 mm Hg or higher, when diastolic BP was in the highest quintile, and when nighttime systolic BP was 124 mm Hg or higher.

Nighttime diastolic BP of 70 mm Hg or higher was a predictor of CV events and end-stage renal disease. Office BP measurement were not predictive of CV or renal events, researchers reported in Archives of Internal Medicine (2011;171:1090-1098).