(HealthDay News) — Atrial fibrillation is associated with a wider range of conditions than previously believed, according to a review and meta-analysis published online in The BMJ.

Ayodele Odutayo, of the University of Oxford in the United Kingdom, and colleagues reviewed 104 studies involving more than 9 million people, including 587,867 patients with atrial fibrillation.

The researchers found that the disorder was also associated with cardiovascular disease, heart failure, chronic kidney disease, sudden cardiac death, and death from all causes. Risk for heart failure was the most significant of these associations, rising 5-fold for patients with atrial fibrillation. But atrial fibrillation was also linked with a 2-fold increased risk of cardiovascular-related death and a 2.3-fold increased risk of stroke. Besides stroke, atrial fibrillation was already tied to an increased risk of death, higher medical costs, and lower quality of life.

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Doctors need to take steps to reduce the risk of these newly identified health risks, along with stroke, in patients with atrial fibrillation, according to the researchers. The findings add “to the growing literature on the association between atrial fibrillation and cardiovascular outcomes beyond stroke,” they write.

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1. Odutayo A, Wong CX, Hsiao AJ, Hopewell S, Altman DG, Emdin CA. Atrial fibrillation and risks of cardiovascular disease, renal disease, and death: systematic review and meta-analysis. BMJ 2016; 354 doi: 10.1136/bmj.i4482.