Risk was increased for those receiving transfusion from donors who later developed multiple spontaneous intracerebral hemorrhages
Whether reducing hemoglobin variability will improve patient outcomes remains unclear.
Study findings challenge purported benefits of transfusing fresh red blood cells.
Additional studies are needed to determine whether anemia itself is a risk factor for dementia in the CKD population.
Large variation in anemia burden by age, sex, geography; burden increased for children younger than 5 years, women, those residing in sub-Saharan Africa and south Asia regions
Risk for anemia incidence and decline in ferritin greater for seniors receiving low-dose aspirin
Use of intravenous iron and ESAs was low among patients with stage 3 to 5 CKD.
The rate of esophageal and gastric erosions among patients on dialysis eligible for anemia treatment was approximately 49 events per 100 patient-years, investigators report.
Patients receiving peritoneal dialysis rather than hemodialysis or both modalities have the lowest rate of ESA hyporesponse.
Patients with persistent ESA hyporesponse had especially high rates of adverse events.