(HealthDay News) — Marathon runners can develop acute kidney injury (AKI) and diagnostic indicators of tubular injury, according to a study published online in the American Journal of Kidney Disease.

Sherry G. Mansour, DO, from the Yale University School of Medicine in New Haven, Conn., and colleagues prospectively collected urine and blood samples from 22 runners (mean age 44 years) participating in the 2015 Hartford Marathon 24 hours before the marathon (day 0), immediately after the marathon (day 1), and 24 hours after the marathon (day 2). Assessed serum markers included creatinine and creatine kinase, while urine markers included urine albumin, injury urine biomarkers (immunoglobulin [IL]-6, IL-8, IL-18, kidney injury molecule 1, neutrophil gelatinase-associated lipocalin, and tumor necrosis factor α), and repair urine biomarkers (YKL-40 and monocyte chemoattractant protein 1).

The researchers found 82% of runners developed an increase in creatinine level equivalent to AKI stages 1 and 2. Microscopy diagnoses of tubular injury were seen in 73% of runners. On day 1, serum creatinine, urine albumin, and injury and repair biomarker levels peaked and were significantly elevated compared to days 0 and 2. From day 0 to day 2, serum creatine kinase levels continued to significantly increase.

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“An increase in injury and repair biomarker levels suggests structural damage to renal tubules occurring after marathon,” the authors write.

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  1. Mansour SG, Verma G, Pata RW, et al. Kidney Injury and Repair Biomarkers in Marathon Runners. Am J Kidney Dis. 28 March 2017. DOI: http://dx.doi.org/10.1053/j.ajkd.2017.01.045