HealthDay News — For critically ill adults, acute kidney injury is a risk factor for delirium and coma, according to a study published online in the American Journal of Respiratory and Critical Care Medicine.

Edward D. Siew, MD, from the Vanderbilt University Medical Center in Nashville, Tenn., and colleagues examined whether acute kidney injury correlates with delirium and coma in 466 critically ill adults in a prospective cohort study. Using multinomial transition models adjusting for demographics, non-renal organ failure, sepsis, prior mental status, and sedative exposure, the authors examined the correlation between acute kidney injury and daily mental status.

The researchers found that stage 2 acute kidney injury was associated with increased risk of delirium and coma (odds ratios, 1.55 and 2.04, respectively), as was stage 3 acute kidney injury (odds ratios, 2.55 and 3.34, respectively). After adjustment for baseline values, daily peak serum creatinine values correlated with delirium and coma (odds ratios, 1.35 and 1.44, respectively). The association between stage 3 acute kidney injury and daily peak serum creatinine and both delirium and coma was modified by renal replacement therapy.

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“Acute kidney injury is a risk factor for delirium and coma during critical illness,” the authors write.

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  1. Siew ED, Fissell WH, Tripp CM, et al. Acute Kidney Injury as a Risk Factor for Delirium and Coma during Critical Illness. Am J Respir Crit Care Med. 17 November 2016. DOI: 10.1164/rccm.201603-0476OC