Acetominophen may help ward off life-threatening kidney damage brought on by statin drug interactions, crush injuries, excessive exercise, or other severe muscle injuries, according to findings published in Proceedings of the National Academy of Sciences (2010;107:2699-2704).

Treatment for such injuries has been limited to the use of intravenous fluids and dialysis, yet in the new investigation, acetaminophen prevented oxidative damage and kidney failure after muscle injury in rats. The drug also improved renal function and reduced renal damage.

These results were observed whether acetaminophen was administered before or after the skeletal muscle injury, and at doses matching normal therapeutic concentrations in humans.

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