GRAPEVINE, Tex.—High levels of uric acid are associated with an increased risk of all-cause and CVD mortality, researchers conclude.


They studied 839 participants in the Modification of Diet in Renal Disease study who had uric acid measurements obtained. The subjects had CKD stages 3 and 4. The investigators, led by Magdalena Madero, MD, found that those in the higher tertile of uric acid concentration (8.4-15.6 mg/dL) had a 57% and 47% increased risk of  all-cause and CVD mortality, respectively, compared with patients in the lowest tertile (1.7-6.9 mg/dL) after adjusting for potential confounders.

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Each 1 mg/dL increase in uric acid was associated with a 17% increase in all-cause mortality and 16% increase in CVD mortality. The patients had a mean age of 52 years; 85% of them were white and 61% were male.


Their mean glomerular filtration rate was 33 mL/min per 1.73 m2 and mean uric acid concentration was 7.63 mg/dL. During a 10-year follow-up, 208 subjects (25%) died from any cause and 127 (15%) died from CVD.


Dr. Madero conducted the study while a fellow at Tufts-New England Medical Center in Boston but she is now based at the Instituto Nacional de Cardiologia Ignacio Chavez in Mexico City. She reported findings here at the National Kidney Foundation’s 2008 Spring Clinical Meetings.