Nephrogenic systemic fibrosis (NSF) is nearly nine times more likely to occur among dialysis patients exposed to gadolinium-containing MRI contrast than in those not exposed, according to a report in the American Journal of Kidney Diseases (2008;51:966-975).


The findings are based on a study of 19 NSF cases and 57 matched controls (dialysis without NSF) by Alexander J. Kallen, MD, MPH, of the Centers for Disease Control and Prevention in Atlanta, and colleagues.

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Their analysis also showed that as the contrast dose increased, so did NSF risk. Moreover, gadodiamide was associated more strongly with NSF than gadoversetamide.