High preoperative C reactive protein (CRP) levels are associated with worse survival in patients who undergo radical nephrectomy for localized renal cell carcinoma (RCC), according to investigators.

Researchers in Japan studied 101 patients. Elevated preoperative CRP was defined as a level greater than 0.5 mg/dL. The median follow-up was 55 months (range 2-187 months).

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Twenty-six patients (26%) had high CRP levels, of whom 12 (46%) died from disease, as did three (4%) of the 75 remaining patients with normal CRP levels, the researchers reported in BJU International (2006;99:77-80). The five- and 10-year disease-specific survival rates in the patients with high CRP (75% and 30%, respectively) were significantly worse than those in patients with normal CRP levels (93% for both).