Pomegranate juice maker POM Wonderful cannot advertise that its pomegranate drinks treat or prevent heart disease or other ailments unless it has proof, a U.S. appeals court said Friday, upholding an order by the Federal Trade Commission.

The U.S. Court of Appeals for the D.C. Circuit largely upheld a 2010 order by the Federal Trade Commission, which found that POM Wonderful’s advertising was misleading in claiming its products would treat or reduce the risk of diseases ranging from heart disease to prostate cancer to erectile dysfunction.

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