Borderline elevation of mean pulmonary artery pressure (BoPAP) — 21 to 24 mm Hg — may represent an intermediate stage between normal pulmonary artery pressures and pulmonary arterial hypertension (PAH) in patients with systemic sclerosis, researchers stated.

A subanalysis of a large multicenter study of systemic sclerosis (SSc) patients at risk for PAH found clinical and laboratory features that may differentiate patients with BoPAP from those with normal mean pulmonary artery pressure (mPAP) and PAH, according to Scott H. Visovatti, MD, of the University of Michigan in Ann Arbor, and colleagues.

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