Long-term antibiotic therapy for men with biopsy-proven asymptomatic prostatitis may not significantly alter elevated PSA levels, data show.


Researchers studied 50 patients with serum PSA level of 4.1-10 ng/mL at the VA Medical Center in Charleston, S.C., who received 45 days of fluoroquinolone therapy for biopsy-proven asymptomatic prostatitis.

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The mean PSA level decreased non-significantly from 6.49 to 6.19 ng/mL, researchers reported. Forty-one patients (82%) had persistently elevated PSA. Thirty biopsies were repeated.

Of these, nine (30%) showed prostate cancer. This is similar to previous studies that have shown that only 20% to 30% of men with PSA levels of 4.1-10.0 ng/mL show prostate cancer in the biopsy. Prostatitis was still present in 18 (60%), according to investigators. BPH was diagnosed in three patients (10%).