Age is an independent prognostic factor in women, but not men, with renal cell carcinoma (RCC), according to researchers.


Allan J. Pantuck, MD, associate professor of urology at the University of California in Los Angeles, and colleagues studied 5,654 RCC patients treated with nephrectomy (67% men, 33% women). The risk of RCC-specific death in women increased 1% with each one-year increment in age.

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As a group, women present with less advanced tumors, resulting in a 19% lower risk of RCC-specific death compared with men.


This survival difference was seen only among patients younger than 60 years. Compared with men, women more frequently had clear-cell RCC (87% vs. 82%) and less frequently had papillary RCC (7% vs. 12%).