Dietary intake of acrylamide, a probable human carcinogen, may be associated with an increased risk of renal cell cancer, according to a report in the American Journal of Clinical Nutrition (2008;87:1428-1438).
Researchers in The Netherlands analyzed data from a subgroup of 5,000 participants in The Netherlands Cohort Study on diet and cancer, which began in 1986.
At baseline, participants filled out self-administered questionnaires on 150 food items and possible risk factors for cancer, such as smoking, occupation, and physical activity. Investigators estimated acrylamide intake from the mean acrylamide concentration of food items and the frequency of consumption and portion size of the food items.
After 13.3 years of follow-up, 339 cases of renal cell cancer, 1,210 cases of bladder cancer, and 2,246 cases of prostate cancer were available for analysis.
Compared with the lowest quintile of acrylamide intake, the highest quintile was associated with a significant 59% increased risk of renal cell cancer, after adjusting for potential confounders. Acrylamide intake was not associated with bladder or prostate cancer.