Industry Supported Education - Renal and Urology News

Industry Supported Education

Diagnosing Primary Hyperoxaluria
Type 1 – a Rare Metabolic Stone Disease

Content sponsored by Alnylam Pharmaceuticals, Inc. Primary hyperoxaluria type 1, or PH1, is a rare life-threatening disease that impacts the kidneys. PH1 is caused by a genetic deficiency in a liver enzyme involved in glyoxylate metabolism, leading to overproduction of oxalate – an insoluble metabolite responsible for the pathophysiology of the disease. Excess oxalate combines…