Industry Supported Education

Oxalate and the Kidneys: Primary Hyperoxaluria in Practice

Content sponsored by Alnylam Pharmaceuticals, Inc. Primary hyperoxaluria (PH) is an autosomal recessive disorder caused by a mutation in one of three liver enzymes resulting in overproduction of oxalate by hepatocytes. PH type 1, or PH1, results from a mutation in the gene AGXT and is overall the most common and severe of the three…

Diagnosing Primary Hyperoxaluria
Type 1 – a Rare Metabolic Stone Disease

Content sponsored by Alnylam Pharmaceuticals, Inc. Primary hyperoxaluria type 1, or PH1, is a rare life-threatening disease that impacts the kidneys. PH1 is caused by a genetic deficiency in a liver enzyme involved in glyoxylate metabolism, leading to overproduction of oxalate – an insoluble metabolite responsible for the pathophysiology of the disease. Excess oxalate combines…

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