Nephrol Dial Trans. 2006;21:3098-3105


Five-year data gathered by the Paulista Registry of Glomerulopathies in São Paulo, Brazil, shows that focal and segmental glomerulosclerosis is the most common primary glomerular disease, followed by membranous nephropathy and IgA nephropathy.

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A team led by Gianna Mastro-ianni-Kirsztajn, MD, of the Univer-sidade Federal de São Paulo, analyzed data from 2,086 patients for whom renal biopsies were performed because of a diagnosis of glomerular disease. The patients had a mean age of 34.5 years.


Among patients with primary glomerular disease, 29.7% had focal segmental glomerulosclerosis, 20.7% had membranous nephropathy, and 17.8% had IgA nephropathy. Another 9.1% had minimal change disease and 7% had membranoproliferative glomerulonephritis.


With respect to secondary glo-merular diseases, lupus nephritis predominated, occurring in 66.2% of cases, followed by post-infectious glomerulonephritis (12.5%) and diabetic nephropathy (6.2%).


Primary glomerular diseases occurred more frequently in males (55.1%), but secondary glomerular diseases were more common in females (71.8%). Nephrotic syndrome was a common presentation.


The authors wrote that their study “contributes to the understanding of the epidemiology of glomerular diseases in Brazil,” with possible implications for transplantation, dialysis, and health politics.