(Transpl Int. 2008;21:985-991)
Diabetic nephropathy and CVD prior to renal transplantation are the most important predictors of post-transplant cardiovascular events, researchers in The Netherlands conclude.
Jeroen Aalten, of Radboud University Medical Center Nijmegen, and colleagues studied 2,187 adult patients who received a first kidney transplant between 1984 and 1997. The study population had a 40% cumulative incidence of post-transplant cardiovascular events.
The incidence was highest in the first three months following transplantation. Pretransplant diabetic nephropathy and claudication were independently associated with a threefold and twofold increased risk of a cardiovascular event after transplantation. A pretransplant cardiac event or cerebrovascular accident were independently associated with 76% and 53% increased risk, respectively.
“Early treatment of cardiovascular risk factors and pretransplant cardiovascular evaluation might improve transplantation outcome,” the authors concluded.