BJU Int. 2008; published online ahead of print

Adjuvant radiotherapy following radical prostatectomy (RP) for prostate cancer has no effect on overall and cancer-specific survival, a Canadian team reports.

Researchers conducted a matched case-control study comparing 118 men who received post-RP adjuvant radiotherapy with controls who did not. The investigators matched patients for pT stage, RP Gleason sum, surgical margin status, age, year of surgery, and administration of hormonal therapy.


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The median follow-up was 11.4 years. The 10- and 20-year overall survival rates were 75.5% and 40%, respectively, for the adjuvant radiotherapy group and 81.1% and 44.8% for controls. The 10- and 20-year cancer-specific survival rates were 86.3% and 69.3% for the adjuvant radiotherapy group and 97.3% and 89% for controls. The differences between the groups were not statistically significant.