Investigators from Baylor College of Medicine in Houston evaluated the correlation between hypogonadal symptoms and serum testosterone levels using the ADAM questionnaire.

In middle-aged men, investigators observed an increased prevalence of symptoms within a testosterone range of 320-375 ng/dL and symptom clusters at levels of 300 ng/dL or less, according to a report published online ahead of print in Urology.

The authors, led by Larry I. Lipshultz, MD, concluded that a “distinct constellation of hypogonadal symptoms exists at various serum testosterone levels.

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Consequently, identification of the thresholds for specific symptom management will be critical in establishing patient-centered treatment algorithms.”