(HealthDay News) — Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is not detected in the semen of patients one month after COVID-19 diagnosis, according to a study published online in Fertility and Sterility.

Feng Pan, MD, from the Huazhong University of Science and Technology in Wuhan, China, and colleagues conducted an observational, cross-sectional study in a tertiary referral center to describe detection of SARS-CoV-2 in seminal fluid of patients recovering from COVID-19. Data were included for 34 Chinese men diagnosed with COVID-19.

The researchers found that around the time of COVID-19 confirmation, 6 of the patients demonstrated scrotal discomfort concerning for viral orchitis. After a median of 31 days from COVID-19 diagnosis, SARS-CoV-2 was not detected in semen samples. Sparse expression of ACE2 and TMPRSS2 was demonstrated in single-cell transcriptome analysis, with almost no overlapping gene expression.

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“We cannot definitively rule out the presence of SARS-CoV-2 in the seminal fluid during an acute infection with severe COVID-19 symptoms,” the authors write. “Further research is needed to understand the long-term impact of SARS-CoV-2 on male reproductive function, including fertility and testicular endocrine function.”


Pan F, Xiao X, Guo J, et al. No evidence of SARS-CoV-2 in semen of males recovering from COVID-19. Fert & Steril. doi: 10.1016/j.fertnstert.2020.04.024

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