Data presented at the recent annual meeting of the American Urological Association show that collagenase injections can decrease penile curvature in men with Peyronie’s disease (PD) compared with placebo, regardless of baseline severity of penile curvature.
The data, reported by Larry Lipshultz, MD, of the Baylor College of Medicine in Houston, and colleagues, are from the randomized, placebo-controlled IMPRESS I and II phase 3 studies of collagenase, which enrolled 303 and 309 men with PD, respectively. Researchers examined treatment outcomes from baseline to 52 weeks. Men with baseline curvature of 30° to 60° responded as well to treatment as subjects with a curvature of 61° to 90°. In IMPRESS I, these men experienced a 39% and 31% improvement from baseline, respectively; in IMPRESS II, they experienced a 28% and 38% improvement.
PD symptom bother score improved by 3.6 and 1.9 points and 2.2 and 3.0 points. All of these improvements were significantly better than those associated with placebo.