Men with hypogonadism who receive anastrozole along with testosterone pellets (TP) maintain therapeutic levels of testosterone (T) longer than those treated with testosterone pellets alone, researchers concluded.

Anastrozole is an aromatase inhibitor that increases T levels by lowering serum estradiol levels and increasing gonadotropin levels.

Clay W. Mechlin, MD, and colleagues at Albany Medical College in Albany, N.Y., studied 38 men who underwent 65 TP insertions. Recipients of TP plus anastrozole had significantly higher total testosterone and free testosterone levels than the men who received TP alone at periods longer than 120 days, according to findings published online ahead of print in the Journal of Sexual Medicine. The TP-only group had significantly higher estradiol levels at all times points. Gonadotropin levels remained stable in the combination therapy arm.

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Dr. Mechlin’s group noted that TP insertions require a minor office procedure every three to four months and the need for repeated insertions increases the likelihood of a complication.