According to the American College of Physicians’ guideline, clinicians should prescribe testosterone treatment only to men with sexual dysfunction symptoms.
Benefits include significant improvement in body composition measurements over 6 months.
Study reveals an approximately 2-fold increased odds of venous thromboembolism associated with testosterone therapy in men with or without hypogonadism
Rates of screening, treatment for low testosterone higher for prolonged versus short-term opioid users
In a study, investigators observed a reduced probability of prostate cancer in nondiabetic men with greater use of testosterone therapy.
Testosterone only recommended for postmenopausal women with hypoactive sexual desire dysfunction
A study of former US professional football players found that the risk of self-reported indicators of low testosterone and erectile dysfunction increased with each successive quartile of concussion symptom score.
Beneficial effects for postmenopausal women, with preference for nonoral testosterone administration
Increased risk in men on TRT for composite of heart attack, ischemic stroke, transient ischemic attack
The increased opioid use has been associated with a rising incidence of opioid-induced endocrinopathy, most commonly in the form of androgen deficiency.