Testosterone use can increase the efficacy of phosphodiesterase type 5 (PDE5)inhibitors in men who have erectile dysfunction that does not respond to thedrugs, according to a recent meta-analysis published online in Expert Opinion onPharmacotherapy.

Although the combination of testosterone replacement and PDE5 inhibitorsshowed greater efficacy in non-controlled studies compared with controlled studies,the authors recommend consideration of testosterone assays in men whofail to respond to PDE5 inhibitors in an effort to optimize outcomes.