Tadalafil (Cialis) may help to ease ejaculatory or orgasmic dysfunction in men with erectile dysfunction (ED), according to an analysis of data from 3,581 men enrolled in 17 randomized, placebo-controlled trials of the drug.
In a study led by Darius A. Paduch, MD, of New York-Presbyterian Hospital/Weill Cornell Medical College in New York, 66% of tadalafil-treated subjects who had severe ejaculatory dysfunction reported improved ejaculatory function compared with 36% who received placebo. In addition, 66% of tadalafil-treated patients with severe orgasmic dysfunction reported improvement compared with 35% of placebo recipients. Residual severe ejaculatory or orgasmic dysfunction after treatment had negative impacts on sexual satisfaction, the researchers reported in BJU International (2013;111:334-343).
In a press release, Dr. Paduch commented that up to 18% of men have a normal erection but do not ejaculate or take a long time to do so. According to Dr. Paduch, non-erectile sexual dysfunction is underreported and undertreated because of social stigma as well as misunderstanding about the physiology of male sexual response and orgasmic dysfunction.