Atorvastatin may yield improvement in patients whose sole risk factor for erectile dysfunction (ED) is hypercholesterolemia.

Turkish researchers studied 25 men with hypercholesterolemia (serum cholesterol level above 200 mg/dL) as a single risk for ED. The patients were instructed to take sildenafil (minimum two 100-mg tablets/week) one hour before sexual intercourse for four weeks.

After a one-month washout period, the patients received a single dose of atorvastatin 10 mg/day for one month. After another one-month washout, atorvastatin 10 mg/day and sildenafil (minimum two 100-mg tablets/week) were administered for one month as combination therapy.

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Following each treatment regimen, mean International Index of Erectile Function (IIEF) scores were significantly higher than baseline IIEF scores, investigators reported in the Scandinavian Journal of Urology and Nephrology (2008; published online ahead of print). The IIEF score was significantly higher after sildenafil treatment than atorvastatin treatment and significantly higher after combination treatment than after sildenafil and atorvastatin treatment alone.