Atorvastatin may yield improvement in patients whose sole risk factor for erectile dysfunction (ED) is hypercholesterolemia.
Turkish researchers studied 25 men with hypercholesterolemia (serum cholesterol level above 200 mg/dL) as a single risk for ED. The patients were instructed to take sildenafil (minimum two 100-mg tablets/week) one hour before sexual intercourse for four weeks.
After a one-month washout period, the patients received a single dose of atorvastatin 10 mg/day for one month. After another one-month washout, atorvastatin 10 mg/day and sildenafil (minimum two 100-mg tablets/week) were administered for one month as combination therapy.
Following each treatment regimen, mean International Index of Erectile Function (IIEF) scores were significantly higher than baseline IIEF scores, investigators reported in the Scandinavian Journal of Urology and Nephrology (2008; published online ahead of print). The IIEF score was significantly higher after sildenafil treatment than atorvastatin treatment and significantly higher after combination treatment than after sildenafil and atorvastatin treatment alone.