(HealthDay News) — Transfusion of convalescent COVID-19 plasma is associated with a reduction in mortality for immunocompromised patients, according to a systematic review published in JAMA Network Open.

Jonathon W. Senefeld, PhD, from the Mayo Clinic in Rochester, Minnesota, and colleagues conducted a systematic review and meta-analysis of trials, studies, and case reports or series on COVID-19 convalescent plasma use in patients who are immunocompromised. The review included three randomized clinical trials enrolling 1487 participants, 5 controlled studies, 125 case series or reports enrolling 265 participants, and 13 uncontrolled large case series with 358 participants.

The researchers found that in separate meta-analyses using models stratified and pooled by study type, COVID-19 convalescent plasma transfusion was associated with a decrease in mortality compared with the control cohort for both randomized clinical trials and matched cohort studies (risk ratio, 0.63).

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“Although these summary findings are encouraging for the use of therapeutic convalescent plasma in COVID-19 patients with primary or secondary immunosuppression, there remains a paucity of well-controlled, published data in these important patient populations,” the authors write. “The clinical use of COVID-19 convalescent plasma and Vax-Plasma in patients who are immunocompromised and have COVID-19 may warrant further investigation.”

One author disclosed financial ties to Sab Therapeutics.

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