(HealthDay News) — Individuals who regularly consume orange juice or grapefruit may have a higher risk of developing melanoma, according to research published online in the Journal of Clinical Oncology.

Abrar Qureshi, M.D., M.P.H., chair of dermatology at Brown University and a dermatologist at Rhode Island Hospital — both in Providence, and colleagues analyzed data from 2 long-running studies of U.S. health professionals involving 105,432 U.S. adults followed for 24 to 26 years. Every 2 to 4 years, the participants answered detailed surveys on their health and lifestyle.

The researchers found that 1,840 people developed melanoma. People who had orange juice at least once a day were about 25% more likely to develop melanoma than those who drank the juice less than weekly. Similarly, people who ate a serving of grapefruit at least 3 times a week had a 41% higher melanoma risk, versus those who never ate it. However, there was no connection between melanoma risk and either whole oranges or grapefruit juice, the researchers found.

Continue Reading

Citrus foods contain particular photoactive chemicals — namely, psoralens and furocoumarins — that are known to make the skin more sensitive to the sun when they’re applied topically, Qureshi told HealthDay. But even if citrus foods potentially make some people susceptible to sunburn, it’s not orange juice that should be avoided. “The citrus can’t hurt you without the excessive sun exposure,” Qureshi said.


  1. Wu, S, et al. Journal of Clinical Oncology, published online before print June 29, 2015; doi: 10.1200/JCO.2014.57.4111.
  2. Marianne Berwick. Journal of Clinical Oncology, published online before print June 29, 2015; doi: 10.1200/JCO.2015.61.8116.