At a Glance
Acquired isolated factor II deficiency is associated with factor II inhibitors.
Based on their effect on prothrombin time (PT), partial thromboplastin time (PTT), and 1:1 mixing study, factor II inhibitors may be non-neutralizing or neutralizing.
What Tests Should I Request to Confirm My Clinical Dx? In addition, what follow-up tests might be useful?
The following test results are consistent with acquired isolated factor to deficiency.
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For non-neutralizing antibodies to factor to which increase the clearance rate of prothrombin and are usually associated with lupus anticoagulant and bleeding:
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Prolonged PT and PTT
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Correction of 1:1 mixing study for the PT and PTT
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Isolated decrease of factor II activity
For neutralizing antibodies that are associated either with bleeding or with recurrent arterial thrombosis:
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Prolonged PT and PTT
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Noncorrection of 1:1 mixing study for the PT and PTT
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Isolated decrease of factor II activity
Are There Any Factors That Might Affect the Lab Results? In particular, does your patient take any medications – OTC drugs or Herbals – that might affect the lab results?
Acquired prothrombin deficiency is seen in patients with liver disease, vitamin K deficiency (malnutrition, antibiotics), or ingestion of vitamin K antagonists, such as warfarin or superwarfarins. In all of these conditions, all vitamin K-dependent factors, including protein C and protein S, are decreased.
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