At a Glance
Prekallikrein deficiency is a rare disorder seen in all ethnic groups. It is autosomal recessive in inheritance. It is associated with a mildly prolonged partial thromboplastin time (PTT) that will correct when incubated on the bench with all reagents for 1 hour. Its deficiency is not associated with bleeding.
Test results consistent with a diagnosis of prekallikrein deficiency include PTT 35-45 sec and a low value for a plasma prekallikrein assay (coagulant or chromogenic).(Table 1)
|APTT||Plasma Prekallikrein Assay|
Are There Any Factors That Might Affect the Lab Results? In particular, does your patient take any medications – OTC drugs or Herbals – that might affect the lab results?
Anticoagulants that interfere with clot-based assay, such as unfractionated heparin, enoxaparin, argatroban, bivalirudin, hirudin, and dabigatran, will interfere with laboratory results.
What Lab Results Are Absolutely Confirmatory?
Low prekallikrein assay with no evidence for a defect in other intrinsic coagulation factors and no lupus anticoagulant is absolutely confirmatory.
Low prekallikrein assay without evidence for an inhibitor to plasma prekallikrein should be requested.
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- At a Glance
- Are There Any Factors That Might Affect the Lab Results? In particular, does your patient take any medications - OTC drugs or Herbals - that might affect the lab results?
- What Lab Results Are Absolutely Confirmatory?