VANCOUVER, B.C.—Elevated serum uric acid levels strongly predict development of albuminuria in patients with chronic kidney disease (CKD), according to researchers in Romania.
Mary Dena, MD, of the Nephrology Clinic at Emergency County Hospital in Craiova, Dolj, Romania, and colleagues studied 125 CKD patients who had no evidence of micro- or macroalbminuria at baseline. The researchers considered the normal range for uric acid to be 3.5-8 mg/dL in men and 3-7.5 mg/dL in women.
After two years, among the patients with hyperuricemia at baseline, 81.25% had albuminuria (micro- or macroalbuminuria), and the patients had a mean reduction in glomerular filtration rate (GFR) of 1.7 mL/min/1.73 m2 per year. In contrast, among patients without hyperuricemia, only 22.22% had albuminuria; these patients had a mean reduction in GFR of 1.1 mL/min/1.73 m2 per year.
After adjustments for numerous covariates, each 1 mg/dL increment in serum uric acid levels was associated with an 80% increased risk of developing albuminuria.