Onset of end-stage kidney disease (ESKD) in patients with autosomal dominant polycystic kidney disease (ADPKD) occurs earlier in Hispanic patients than in those of other races, according to study findings presented at the virtual National Kidney Foundation 2021 Spring Clinical Meetings.

In a study of 3868 patients with ADPKD, Teresa N. Harrison, SM, of Kaiser Permanente Research & Evaluation in Pasadena, California, found that the mean age of ESKD onset was 50 years among Hispanic patients compared with 53, 56, and 57 years among Asian, Black, and White patients, respectively.

“To our knowledge, this study is one of the first to include Hispanic and Asian ADPKD patients and to report race/ethnic differences in the onset of ESKD,” the authors concluded.

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The investigators defined ESKD onset as the initiation of dialysis or receipt of a kidney transplant.

The racial or ethnic distribution of patients in the cohort was 42% White, 32% Hispanic, 12% Black, and 10% Asian. Patients had a mean baseline estimated glomerular filtration rate of 67.4 mL/min/1.73 m2. The most common comorbidity was hypertension (53.5%), followed by abdominal pain (37.3%) and hyperlipidemia (32.7%). ESKD developed in 27% of the cohort.

The investigators pointed out that the study was limited by its retrospective design and its findings depended on the availability and accuracy of existing records. In addition, the study analyzed data from patients within a single, integrated healthcare system and therefore may not be generalizable to other settings, Harrison’s team noted.

Disclosure: This study was supported by Otsuka Pharmaceutical. Please see the original reference for a full list of authors’ disclosures.


Harrison TN, Chen Q, Willey C, et al. Autosomal dominant polycystic kidney disease: age of onset of end stage kidney disease by race/ethnicity. Presented at the virtual National Kidney Foundation 2021 Spring Clinical Meetings, April 6-10. Poster 212.