|The following article features coverage from the National Kidney Foundation’s virtual 2020 Spring Clinical Meetings. Click here to read more of Renal and Urology News’ conference coverage.|
Metabolic acidosis is associated with an increased risk of death among patients with chronic kidney disease (CKD), according to study findings presented at the live virtual 2020 National Kidney Foundation Spring Clinical Meetings.
The finding is from a longitudinal observational study that included 51,558 patients with non-dialysis-dependent CKD. The study population included 17,350 patients with metabolic acidosis (serum bicarbonate level 12 to 22 mEq/L) and 34,208 patients with normal serum bicarbonate levels (22 to 29 mEq/L). The 2-year mortality rate was significantly higher in the metabolic acidosis cohort than the normal serum bicarbonate cohort (30.9% vs 10.2%), Navdeep Tangri, MD, PhD, of the University of Manitoba in Winnipeg, Canada, and colleagues reported in a poster presentation.
The 2-year mortality rate in the normal serum bicarbonate cohort increased along with CKD stage, from 7.9% among patients with CKD stage 3a to 19.9% of patients with CKD stage 5. The 2-year mortality rate in the metabolic acidosis cohort remained relatively consistent across CKD stages at a mean of 31%, Dr Tangri’s group reported.
Each 1 mEq/L improvement in serum bicarbonate was significantly associated with a 9% decreased risk of death after adjusting for age, sex, race, pre-existing comorbidities, and baseline estimated glomerular filtration rate and albumin-to-creatinine ratio.
The metabolic acidosis cohort was younger than the normal serum bicarbonate cohort (mean 70.3 vs 74.3 years) and had a higher comorbidity burden.
Read more of our coverage of the National Kidney Foundation’s virtual 2020 Spring Clinical Meetings by visiting the conference page.
Tangri N, Reaven N, Funk SE, Mathur V. Metabolic acidosis is a predictive factor for all-cause mortality in patients with chronic kidney disease. Data presented at the live virtual 2020 National Kidney Foundation Spring Clinical Meetings held March 25 to 29. ePoster 263.