|The following article features coverage from the National Kidney Foundation’s virtual 2020 Spring Clinical Meetings. Click here to read more of Renal and Urology News’ conference coverage.|
Kidney transplant recipients (KTRs) who lose their allograft as a result of BK virus nephropathy (BKVN) do so earlier than KTRs who lose their allograft due to other causes, new study findings presented at the live virtual 2020 National Kidney Foundation Spring Clinical Meetings suggest.
Risk factors significantly associated with BKVN graft loss compared with graft loss from other causes include older recipient age, male gender, preemptive transplant, HLA mismatch ≥3, and longer dialysis vintage.
The study was retrospective cohort analysis using the United Network for Organ Sharing database. Investigators identified all patients who received a transplant from January 2000 to December 2018 (332,649) and those who experienced graft failure due to BKVN (1392 patients) and graft failure due to other causes (56,319 patients).
Death-censored median graft survival times were significantly shorter in the BKVN graft loss group (median 943 vs 1440 days), Het A. Patel, MD, of Harvard Medical School in Boston, and colleagues reported in a poster presentation. Compared with KTRs who lost their graft from causes other than BKVN, those with BKVN-related graft loss were significantly older (median age 52 vs 45 years) and were significantly more likely to be male (72.2% vs. 58.7%), more likely to have had a preemptive transplant (15.9% vs 13.3%), and had a significantly longer dialysis vintage (median 1073 vs 981 days).
In a separate analysis comparing the BKVN graft loss group with 274,938 KTRs who had a functioning graft, the same research team identified non-preemptive transplantation, delayed graft function, longer dialysis vintage, male gender, and African-American race as risk factors for BKVN graft loss.
Patel H, Agarwal K, Aditya P, et al. Comparative analysis of risk factors for kidney allograft loss due to BK nephropathy and graft loss due to other causes: UNOS data set. Data presented at the live virtual 2020 National Kidney Foundation Spring Clinical Meetings held March 25 to 29. ePoster 464.
Patel H, Agarwal K, Aditya P, et al. Incidence and risk factors of kidney allograft loss due to BK virus: UNOS data set. Data presented at the live virtual 2020 National Kidney Foundation Spring Clinical Meetings held March 25 to 28. ePoster 465.