Gender and need for continuous renal replacement therapy (CRRT) do not affect the risk for in-hospital mortality among adult patients with concomitant acute kidney injury (AKI) and acute respiratory distress syndrome (ARDS), investigators reported at the National Kidney Foundation’s 2022 Spring Clinical Meetings in Boston, Massachusetts.

Female vs male sex, however, is associated with longer hospital stays. In addition, the greater the comorbidity burden, the greater the risk for death.

The study, by Bilal Malik, MD, of McLaren Flint & Michigan State University College of Human Medicine in Flint, Michigan, and colleagues, included 650 patients hospitalized with ARDS and co-existing AKI identified using the National Inpatient Sample (2016-2019). Of the cohort, 3.8% required CRRT at some point during their hospitalization.

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Compared with a Charlson Comorbidity Index (CCI) of 0, a CCI of 1 or 2 was significantly associated with approximately 6-fold increased odds of in-hospital mortality, in adjusted analyses, the investigators reported. A CCI of 3 or higher was associated with borderline significant 4.1-fold increased odds of in-hospital mortality.

Women had a significantly longer hospital length of stay (LOS) than men (15.6 vs 7.6 days). Dr Malik’s group also identified a declining trend in LOS, which decreased from 17.2 days in 2016 to 10.5, 7.2, and 11.2 days in 2017, 2018, and 2019, respectively.


Malik B, Baral N, Abdelazeem B, et al. Trends, outcomes, and gender-based differences in patients with ARDS and coexisting acute renal failure. Presented at the National Kidney Foundation’s 2022 Spring Clinical Meetings, Boston, Massachusetts, April 6-10, 2022. Poster 14.