Acute kidney injury (AKI) and acute kidney disease (AKD) are common side effects from radical cystectomy for muscle-invasive bladder cancer (MIBC), according to data presented at the American Society of Nephrology’s Kidney Week 2022 conference in Orlando, Florida.

Investigators identified hypertension at baseline as a unique risk factor for these complications.

Francesco Trevisani, MD, of IRCCS Ospedale San Raffaele in Milan, Italy, and colleagues studied 280 patients who underwent radical cystectomy for MIBC. AKI and AKD developed in 51.4% and 37.5% of patients, respectively, the investigators reported in a poster presentation. Both AKI and AKD occurred in 23.6% of patients, whereas 13.9% of patients experienced AKD, but not AKI. Surgical approach was not a factor.

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Baseline hypertension was present in 63% of patients with AKI and AKD compared with 46% of patients without AKI and AKD, according to the investigators.

The authors concluded that AKI and AKD are frequent side effects of radical cystectomy for MIBC and require nephrological counseling immediately after the procedure to monitor for onset of both complications.


Trevisani F, Cinque A, Floris M, et al. AKI and acute kidney disease after radical cystectomy for muscle-invasive bladder cancer: A hidden uro-nephrological affair. Presented at: Kidney Week 2022; November 3-6, Orlando, Florida. Abstract TH-PO075.