Methotrexate Added to Pegloticase for Gout Safe for Kidneys
Investigators report findings from the MIRROR RCT trial, which compared pegloticase plus methotrexate vs placebo for uncontrolled gout.
Kidney Week 2022
Conference Coverage
Prostate Cancer More Likely To Be Treated in Patients on Dialysis
New findings suggest active surveillance should be performed in this population and should not preclude transplant eligibility, according to investigators.
Kidney Function Declines More Slowly With SGLT2 Inhibitor
Treatment with an SGLT2 inhibitor may help patients with CKD or type 2 diabetes better preserve their kidney function.
AKI, AKD Are Common Complications of Radical Cystectomy
In a study, acute kidney injury and acute kidney disease developed in 51.4% and 37.5% of patients who underwent radical cystectomy for muscle-invasive bladder cancer.
Rapid Weight Loss May Be Risky in CKD
Study underscores the importance of maintaining or increasing lean body mass during weight loss.
Intravenous vs Oral Iron Does Not Increase CKD Risk
Investigators compared the therapies in a large national cohort of patients with normal kidney function.
Empagliflozin May Reduce Stone Risk
Data from real-world practice and a meta-analysis of randomized controlled trials concur.
How US CKD Prevalence Shifts Using Age-Adapted CKD Classification
A greater proportion of younger adults are at risk under the age-adapted CKD classification system.
Chronic Kidney Disease Linked to Bicarbonate Therapy
Study of US veterans with normal kidney function at baseline found that bicarbonate users had a significant 2.0- and 3.3-fold increased risk for incident CKD and death, respectively.
Proteinuria, AKI With New Tyrosine Kinase Inhibitors Characterized
Since FDA approval of imtainib, 40 newer tyrosine kinase inhibitor agents have been approved.
Hyperkalemia Is a Strong Risk Factor for Early Death in Stage 5 CKD
New findings have important implications in the new era where delaying dialysis initiation is a priority goal by means of continued conservative management of hyperkalemia, according to investigators.
Nephrologists Lag Behind Other Physicians in Prescribing SGLT2 Inhibitors
In the final 12 months of a 7-year study period (January 2015 to April 2022), endocrinologists accounted for 11-fold more SGLT2 inhibitor prescriptions than nephrologists, investigators report.
Statins May Reduce Contrast-Induced Acute Kidney Injury
Given the widespread use of contrast medium in cardiovascular and other imaging, continued focus on preventing contrast-induced acute kidney injury is warranted.
AKI Risk Factors and Outcomes in Living Kidney Donors Characterized
Demand for living kidney donors has only grown, spurring investigators to study the risks and health consequences of donation, such as acute kidney injury.
Hyponatremia Linked to Dementia
Patients with hyponatremia and other risk factors for dementia might need closer monitoring.
AKI, CKD Progression Less Likely With Direct Oral Anticoagulants
Danish investigators compared direct oral anticoagulants with vitamin K antagonists in 33,670 patients with atrial fibrillation.
Heart Failure Linked to Iron Deficiency in Older Adults
Recent study included 980 individuals older than 65 years who participated in the Cardiovascular Health Study.
End-Stage Kidney Disease More Likely in Underweight Individuals
Underweight also has been linked to cardiovascular disease and early mortality in a general population.
Trial Explores Iron Dose to Maintain Hemoglobin, Minimize ESAs in Hemodialysis
Currently, there is no standard regimen for maintenance iron supplementation in patients receiving hemodialysis.
Stopping RAS Inhibitors in Advanced CKD Does Not Significantly Change eGFR
If renin-angiotensin system inhibitors are indicated in patients with advanced CKD, they should not be stopped just because of low eGFR, investigators concluded.
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