Previous research has found that dyslipidemia may be a risk factor for new-onset chronic kidney disease (CKD). Now new study findings presented at the American Society of Nephrology’s Kidney Week 2020 Reimagined virtual conference suggest that CKD may lead to new-onset dyslipidemia.
Using the Japanese Specific Health Check and Guidance System, Takaaki Kosugi, MD, of Nara Medical University in Kashihara, Nara, Japan, and colleagues identified 51,009 patients with CKD and 254,884 without CKD who were free of dyslipidemia at baseline. Over a median 3.1 years, 14.8%, 17.0%, and 4.3% of individuals developed high levels of triglycerides (150 mg/dL or greater) and low-density lipoprotein (LDL; 140 mg/dL or greater) and low levels of high-density lipoprotein (HDL; less than 40 mg/dL), respectively.
In univariable analyses, patients with CKD had 29%, 3.0%, and 68% greater risks for high triglycerides, high LDL, and low HDL, respectively, than patients without CKD. After adjustment, however, CKD patients had significant 9% and 12% greater risks for high triglycerides and low HDL, respectively, but no elevated risk for high LDL, compared with patients who did not have CKD.
CKD is associated with new onset hypertriglyceridemia and hypo-HDL cholesterolemia among the general population in Japan, Dr Kosugi’s team concluded. In turn, dyslipidemia is a significant risk factor for cardiovascular disease, a leading cause of death in this population.
Kosugi T, Eriguchi M, Yoshida H, et al. Association between CKD and new onset of dyslipidemia: results from a longitudinal nationwide survey. Presented at: Kidney Week 2020 Reimagined, October 19-25, 2020. Poster PO0464.