The following article features coverage from Kidney Week 2019. Click here to read more of Renal & Urology News’ conference coverage.

WASHINGTON—High serum calcium and parathyroid hormone (PTH) levels are risk factors for intradialytic hypotension (IDH) in patients on hemodialysis, new data presented at the American Society of Nephrology’s 2019 Kidney Week conference suggest.

In a retrospective study of 922 hemodialysis patients in China, investigators demonstrated that 21.1% of patients with high serum calcium (8.67 mg/dL [the median for the entire study population] or higher) and high PTH (intact PTH [iPTH] above 300 pg/mL) had IDH compared with 9.6% of patients with low serum calcium (less than 8.67 mg/dL) and low PTH (iPTH 300 pg/mL or less).

After adjusting for age, sex, presence of diabetes mellitus, dialysis vintage and other potential confounders, hypercalcemia by itself was significantly associated with nearly 2.5-fold increased odds of IDH, Ning Su, MD, and colleagues at The Sixth Affiliated Hospital of Sun Yat-sen University in Guangzhou, China, reported in a poster presentation. Hypercalcemia accompanied by high iPTH was significantly associated with 2.6-fold increased odds of IDH.

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In addition, the investigators found that increasing ultrafiltration was significantly associated with nearly 1.4-fold increased odds of IDH, whereas hemodiafiltration was significantly associated with an almost 56% decreased odds of IDH.

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Su N, Liang M, Jiang Z. High serum calcium and parathyroid hormone are risk factors of intradialytic hypotension in hemodialysis patients. Presented in poster format on November 7, 2019, at the American Society of Nephrology’s annual Kidney Week conference in Washington, DC. Abstract TH-PO223.