The following article is part of conference coverage from Kidney Week 2017 in New Orleans hosted by the American Society of Nephrology. Renal & Urology News staff will be reporting live on medical studies conducted by nephrologists and other specialists who are tops in their field in acute kidney injury, chronic kidney disease, dialysis, transplantation, and more. Check back for the latest news from Kidney Week 2017.

NEW ORLEANS—Intravenous treatment with paricalcitol alone shows the most efficacy in lowering intact parathyroid hormone (iPTH) levels in hemodialysis patients with secondary hyperparathyroidism (SHPT), investigators reported at Kidney Week 2017.

“Treatment with intravenous paricalcitol should be considered for all hemodialyzed patients with inadequate serum PTH level control,” lead investigator Jacek Zawierucha, MD, of Fresenius Medicare Care Polska SA in Poland, told Renal & Urology News. “SHPT treatment with cinacalcet should be considered for peritoneal dialysis patients and when severe hypercalcemia occurs.”

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Of 131 patients with elevated iPTH (mean 1072 pg/mL), 60 received paricalcitol alone, 50 cinacalcet alone, and 21 a combination of cinacalcet and paricalcitol (after unsatisfactory results with cinacalcet monotherapy).

At 1 year, all groups experienced significant decline in iPTH, with the lowest level achieved in the paricalcitol-only group: 369 pg/mL vs 536 pg/mL with cinacalcet alone and 743 pg/mL for the combined treatment.

According to the investigators, iPTH dropped to its lowest levels (390 pg/mL) after 3 months of therapy, then stabilized. The team suggested reevaluating the treatment strategy when a patient has inadequate response after 3 months.

All 3 strategies showed similar safety. There were no episodes of severe hypercalcemia or hypocalcemia.

The study was funded by Fresenius Medical Care, which manufactures paricalcitol. The team is planning a future clinical trial with a greater number of patients.

Visit Renal & Urology News’ conference section for continuous coverage from Kidney Week 2017.

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1. Zawierucha JP, Malyszko J, Malyszko JS, et al. Secondary hyperparathyroidism in hemodialysed patients – Comparison of the most common strategies of treatment in a one-year observational study. Presented in poster format at Kidney Week 2017 in New Orleans (Oct. 31-Nov.5). Abstract FR-PO289.