SAN DIEGO—Sucroferric oxyhydroxide significantly decreases serum phosphorus levels and phosphate binder pill burden in peritoneal dialysis patients, according to study findings presented at Kidney Week.
In a retrospective study of 328 patients with high baseline phosphorus levels, a team led by Linda H. Ficociello, DSc, of Fresenius Medical Care North America in Waltham, Mass., observed a significant mean decline in phosphorus level from 6.92 mg/dL at baseline to 6.67 mg/dL after 3 months of treatment with sucroferric oxyhydroxide. In addition, results showed a significant 55% decrease in phosphate binder pills per day (from 8.4 to 3.8 pills), a significant 76% increase in the proportion of patients with serum phosphorus levels of 3.5–5.5 mg/dL, and a significant 21% increase in the proportion of patients with calcium × phosphorus product less than 55 mg2/dL2.
In a poster presentation, the investigators cited previous studies showing that a high pill burden among dialysis patients is associated with patient non-adherence to phosphate binder therapy and elevated serum phosphorus levels.
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Study patients had an average age of 53 years and dialysis vintage of 3.9 years. At baseline, phosphate binder therapy consisted of sevelamer (55.8% of patients), calcium acetate (29%), calcium carbonate (10.7%), and combination therapy (4.5%).
