PHILADELPHIA—Patients with a history of kidney stones are at significantly higher risk of renal cell carcinoma (RCC) and transitional cell carcinoma (TCC), according to the findings of a meta-analysis presented at the 2014 Kidney Week meeting.

The meta-analysis, by Wisit Cheungpasitporn, MD, of Mayo Clinic in Rochester, Minn., and colleagues, included 7 studies. A history of kidney stones was associated with a significant 76% increased risk of RCC and a 2.1 times increased risk of TCC.

In subgroup analyses, the risk of RCC associated with stones was significant only in male subjects. The researchers concluded that their findings may impact clinical management and cancer surveillance.

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