ATLANTA—Kidney stone formers may be at increased risk for wrist fractures, new findings presented at the American Society of Nephrology’s Kidney Week 2013 meeting suggest.
Eric N. Taylor, MD, and Gary C. Curhan, MD, ScD, of Brigham and Women’s Hospital in Boston, examined the association between nephrolithiasis and wrist and hip fractures in 77,055 women in the Nurses’ Health Study I and 50,982 men in the Health Professionals Follow-up Study. The period of follow-up was 30 years and 24 years, respectively. The study excluded pre-menopausal women, men younger than 45 years and individuals who reported osteoporosis at baseline.
During follow-up, 3,741 wrist fractures and 1,160 hip fractures occurred in the women and 859 wrist fractures and 634 hip fractures occurred in the men. Women and men with a history of kidney stones had a 36% and 22% increased risk of wrist fracture compared with women and men who did not have history of kidney stones. The researchers found no association between kidney stone history and hip fractures.
More than 77% of stones were composed of calcium oxalate. At baseline, subjects with a history of kidney stones had a higher body mass index and were more likely to use a thiazide diuretic than those without a history of kidney stones.