The researchers, led by Mona D. Doshi, MD, Assistant Professor of Medicine at Wayne State University in Detroit, compared 138 African-Americans who underwent a donor nephrectomy and 48 African-Americans who were suitable candidates for live kidney donation but did not donate because of non-medical reasons. None of the donors had either hypertension or diabetes prior to donation.
After a median follow-up of seven years (range 4-18 years), 69 donors (50%) had hypertension (either a systolic pressure greater than 140 mm Hg, a diastolic pressure greater than 90 mm Hg, or the use of antihypertensive medications) compared with 13 non-donors (27%). Donors had a significant 2.4 times increased risk of hypertension compared with non-donors, after adjusting for potential confounding variables. In addition, 52% of donors were not seeing a physician regularly and 49% of those with hypertension were not being treated for the condition.