PHILADELPHIA—Coronary artery calcification (CAC) provides additional predictive value for the risk of myocardial infarction (MI) in patients with chronic kidney disease (CKD), according to data presented at Kidney Week 2011.
Investigators noted that vascular calcification is associated with increased cardiovascular disease (CVD) risk and mortality in dialysis patients. The predictive value of CAC on clinical CVD has not been well studied in CKD patients.
In a study of 1,704 CKD patients who participated in the Chronic Renal Insufficiency Cohort (CRIC) study, Jing Chen, MD, and colleagues at Tulane University in New Orleans found that subjects with moderate to severe CAC had a 3.1 and 11.3 times increased risk for MI, respectively, a 1.8 and 4.4 times increased risk for congestive heart failure, a 2.3 and 4.5 times increased risk for total cardiovascular disease (CVD), and a 2.2 and 4.1 times increased risk for all-cause mortality, after adjusting for age, gender, race, and clinical sites.
After further adjustment for established CVD risk factors, including estimated glomerular filtration rate and history of CVD, severe CAC was only significantly associated with MI, conferring a sixfold increased risk compared with no CAC.