Loop diuretic use at the time of peritoneal dialysis (PD) is not associated with improved outcomes, according to data presented during Kidney Week 2021, a virtual meeting of the American Society of Nephrology.
Jiacong Luo, MD, of DaVita Clinical Research in Minneapolis, Minnesota, and colleagues conducted a retrospective study involving electronic health records and US Renal Data System claims data. The investigators assessed outcomes from day 91 of PD through death, loss to follow-up, or study end (December 31, 2014). The study included patients who started PD at a large dialysis organization from January 1, 2006 to June 30, 2014.
The hospitalization rate during follow-up was 1.77 admissions per patient-year among the 792 patients initiating PD with a loop diuretic prescription compared with 1.75 admissions per patient-year for the 1363 patients without such a prescription, the investigators reported. These between-group differences were not statistically significant. The 2 groups had similar mortality rates, with crude rates of 0.21 and 0.18 deaths per patient-year, respectively.
Dr Luo and colleagues found no substantial difference between the groups with respect to serum potassium levels, renal Kt/V, and time to transition to hemodialysis.
Previous research has shown that loop diuretic use at the time of dialysis initiation among patients receiving hemodialysis is associated with a lower hospitalization rate and other favorable outcomes.
Luo J, Cohen DE, Colson C, Brunelli SM, Tentori F, Schreiber MJ. Associations between loop diuretic use and outcomes among patients treated with peritoneal dialysis. Presented at: Kidney Week 2021, November 2-7, 2021. Abstract PO0990.