ATLANTA—Greater waist circumference is associated with an increased risk of end-stage renal disease (ESRD) after adjusting for body mass index (BMI), according to study findings presented at the American Society of Nephrology’s Kidney Week 2013. The findings support the hypothesis that increased abdominal adiposity may influence kidney disease progression, researchers concluded.

The study also showed that higher BMI is associated with a decreased risk of ESRD after adjusting for waist circumference.

In a study that included 27,085 participants in the REGARDS trial, Holly J. Kramer, MD, of Loyola University in Chicago, and colleagues found a lower prevalence of albuminuria and chronic kidney disease among subjects with a BMI of 25 kg/m2 or higher compared with those who had a lower BMI, but a higher prevalence among participants with a waist circumference of 80 cm or greater (for women) and 94 cm or greater (for men) compared with those who had a waist circumference less than 80 cm and less than 94 cm, respectively.

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ESRD developed in 160 participants (0.6%). Increased BMI was associated with a decreased risk of ESRD after adjustment for waist circumference and other variables, whereas greater waist circumference was associated with an increased ESRD risk.