PHILADELPHIA—Combination drug therapy for hypertension is associated with worse nocturia and nocturnal polyuria than untreated hypertension or single-drug therapy, investigators reported at the International Continence Society’s 2018 annual meeting.

In a study of 184 voiding diaries completed by 184 men receiving care at a Veterans Affairs-based urology clinic, men who took multiple blood pressure (BP) drugs had significantly more nocturnal voids than men taking a single BP drug and those with untreated hypertension (median 3.0 vs. 2.5 and 2.5, respectively), a team led by Jeffrey Weiss, MD, of SUNY Downstate College of Medicine in Brooklyn, New York, reported in a poster presentation.

Men taking multiple BP drugs also had a significantly higher nocturnal polyuria index (47% vs 40% and 38%, respectively) and a significantly higher nocturnal bladder capacity index (1.53 vs 1.10 and 1.23, respectively).

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“Patients requiring multiple antihypertensive drugs are likely to have more severe and long-lasting hypertension, with impairment of both nocturnal dipping of blood pressure and renal tubular sodium and water transplant,” the authors concluded.

These abnormalities are thought to have a role in driving nocturnal polyuria, according to the investigators.


Epstein M, Monaghan T, Victor R, Weiss J. Relationship of nocturnal polyuria and combination anti-hypertensive drug therapy. Data presented at the International Continence Society’s 2018 annual meeting in Philadelphia, August 28–31. Abstract 107.